Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/14712
Title: Physiochemical properties and antitumor activities of two alpha-glucans isolated from hot water and alkaline extracts of Cordyceps (Cs-HK1) fungal mycelia
Authors: Yan, JK
Wang, WQ
Li, L
Wu, JY 
Keywords: Medicinal fungus
Polysaccharides
Structure
Conformation
Antitumor activity
Issue Date: 2011
Publisher: Elsevier Sci Ltd
Source: Carbohydrate polymers, 2011, v. 85, no. 4, p. 753-758 How to cite?
Journal: Carbohydrate Polymers 
Abstract: Two novel polysaccharides, WIPS and AIPS, were isolated and fractionated respectively from hot water and alkaline extracts of the mycelial biomass of a medicinal fungus Cordyceps sinensis (strain Cs-HK1). Through analytical and degradation experiments, WIPS and AIPS were characterized as alpha-D-glucans with a backbone of (1 -> 4)-linked alpha-D-Glcp (>60%) and very similar molecular weights (M(w): WIPS 1180 kDa: AIPS 1150 kDa). WIPS had a short branch of (1 6)-linked alpha-D-Glcp (similar to 14%), but AIPS was a linear glucan, distinctive from the branched structures of most glucans from medicinal fungi. In aqueous alkaline solutions, both AIPS and WIPS exhibited a random coil structure with the similar conformational parameters but significantly different polydispersity indexes, 0.19 versus 0.37. AIPS exhibited much more significant antitumor and immuno-stimulatory effects than WIPS in animal tests on melanoma tumor-bearing mice.
URI: http://hdl.handle.net/10397/14712
ISSN: 0144-8617
DOI: 10.1016/j.carbpol.2011.03.043
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