Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/14047
Title: Antiproliferative activity of the extract of Gleditsia sinensis fruit on human solid tumour cell lines
Authors: Chow, LMC 
Tang, JCO 
Teo, ITN
Chui, CH
Lau, FY
Leung, TWT
Cheng, G
Wong, RSM
Wong, ILK
Tsang, KMS
Tan, WQ
Zhao, YZ
Lai, KB
Lam, WH
Guo, DA
Chan, ASC
Keywords: Apoptosis
Herbal drugs
Tumour
Issue Date: 2002
Publisher: Karger
Source: Chemotherapy, 2002, v. 48, no. 6, p. 303-308 How to cite?
Journal: Chemotherapy 
Abstract: Background: The fruit extract of Gleditsia sinensis Lam. (GSE) is a traditional herbal medicine that is saponinrich. However, its activity on solid tumour cell lines has never been demonstrated. Methods: The activity of GSE was demonstrated in four cancer cell lines (breast cancer MCF-7, MDA-MB231, hepatoblastoma HepG2 and oesophageal squamous carcinoma cell line SLMT-1) using MTT assay, anchorage-independent clonogenicity assay, DNA laddering and in situ cell death detection. Results: The mean MTT 50 (the mean concentration of GSE to reduce MTT activity by 50%) ranged from 16 to 20 £gg/ml of GSE. An anchorage-independent clonogenicity assay showed that all of the four solid tumour cell lines gradually lost their regeneration potential after treatment with GSE, DNA fragmentation and TUNEL analysis demonstrated that the action of GSE is both dose- and time course-dependent. Conclusions: Our results suggest that GSE has a cytotoxic activity and can induce apoptosis in human solid tumour cell lines.
URI: http://hdl.handle.net/10397/14047
ISSN: 0009-3157
DOI: 10.1159/000069713
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