Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/13884
Title: A convenient synthesis of 2,2 ',6,6 '-tetramethoxy-4,4 '-bis(dicyclohexylphosphino)-3,3 '-bipyridine (Cy-P-Phos) : application in Rh-catalyzed asymmetric hydrogenation of alpha-(acylamino)acrylates
Authors: Wu, J
Au Yeung, TTL
Kwok, WH
Ji, JX
Zhou, ZY
Yeung, CH
Chan, ASC
Keywords: Alpha-(acylamino)acrylates
Asymmetric hydrogenation
Dipyridylphosphine
Homogeneous catalysis
Rhodium
Issue Date: 2005
Publisher: Wiley-VCH
Source: Advanced synthesis & catalysis, 2005, v. 347, no. 4, p. 507-511 How to cite?
Journal: Advanced synthesis & catalysis 
Abstract: The first example of the synthesis of an axially chiral bis(aryldicyclohexylpilosphine) dioxide via catalytic hydrogenation of the optically resolved parent bis(aryldiphenylphosphine) dioxide was reported. The procedure for the synthesis of Cy-P-Phos (4d) has thus successfully avoided the need for an otherwise lengthy synthetic route owing to the pi-excessive nature of one of the aryl groups in the latter. The use of Cy-P-Phos in the Rh(I)-catalyzed asymmetric hydrogenation of the derivatives of methyl (Z)-2-acetamidocinnamate gave significantly higher rates of reaction as compared to the use of the previously reported optimal ligand Xyl-P-Phos (4c) whilst the level of enantioselectivity was essentially maintained.
URI: http://hdl.handle.net/10397/13884
ISSN: 1615-4150
EISSN: 1615-4169
DOI: 10.1002/adsc.200404310
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