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Title: Differential protein expression induced by a lipid extract of perna canaliculus in splenocytes of rats with adjuvant-induced arthritis
Authors: Lee, C
Butt, YK
Wong, M 
Lo, SC 
Keywords: Lyprinol
Adjuvant-induced arthritis
Malate dehydrogenase
Protein disulfide isomerase
Titin-cap protein
Tdrd7 protein
Issue Date: 2008
Publisher: Springer
Source: Inflammopharmacology, 2008, v. 16, no. 4, p. 188-194 How to cite?
Journal: Inflammopharmacology 
Abstract: The lipid extract of Perna canaliculus (Lyprinol®) has known anti-inflammatory effects. However, the only information on mechanisms is regulation of cytokine secretion. Therefore, we conducted a proteomic study exploring the effects of Lyprinol on protein expression in splenocytes collected from AIA rats. Splenocytes from AIA rats fed with Lyprinol had increased protein expression of malate dehydrogenase (MDH). Lyprinol also decreased the expressions of 5 other proteins: protein-o-mannosyl- transferase 2 (PMT-2), Tdrd 7, telethonin, dynactin 2 and protein disulfide isomerase (PDI or glucose-regulated protein (GRP)). Besides MDH, PMT- 2, titin-cap protein and protein disulfide isomerase (PDI) are known to be related to metabolism. However, it is currently unknown if Lyprinol administration decreases metabolic glucose in the body and alleviates symptoms of inflammation and arthritis. Further experiments are required to correlate levels of citric acid intermediates and glucose to the severity of inflammation and pain in AIA rats fed Lyprinol.
ISSN: 0925-4692
EISSN: 1568-5608
DOI: 10.1007/s10787-008-8010-2
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