Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/13644
Title: Potential antioxidant, antiinflammatory, and proapoptotic anticancer activities of Kakadu plum and Illawarra plum polyphenolic fractions
Authors: Tan, AC
Konczak, I
Ramzan, I
Zabaras, D
Sze, DMY
Issue Date: 2011
Publisher: Routledge, Taylor & Francis Group
Source: Nutrition and cancer, 2011, v. 63, no. 7, p. 1074-1084 How to cite?
Journal: Nutrition and cancer 
Abstract: Kakadu plum (Terminalia ferdinandiana Exell, Combretaceae) and Illawarra plum (Podocarpus elatus Endl., Podocarpaceae) extracts were fractionated, using a bioassay-guided approach and screened for antioxidant activity [oxygen radical absorbance capacity (ORAC) and cellular antioxidant activity (CAA) assays] and antiinflammatory activity (nitrite concentration and prostaglandin E 2 release in lipopolysaccharide (LPS)-activated murine macrophages). Among 8 fractions obtained from KP and 5 fractions obtained from IP, fraction KPF5 from KP exhibited superior activity in all assays, with an ORAC value of 3,776 ± 603 μmol Trolox/g DW and a CAA value of 52.2 ± 8.6 μmol quercetin equivalents/g DW. In addition, KPF5 further demonstrated an upregulation of the Nrf2/Keap1 ratio in Hep G2 cells. KPF5 also inhibited the expression of COX-2 and iNOS in LPS-activated murine macrophages, potentially through the NF-κB, p44/42 mitogen activated protein kinase and Akt pathways. KPF5 also induced apoptosis and DNA damage in HT-29 cells, as determined by the cytokinesis block micronucleus cytome assay.
URI: http://hdl.handle.net/10397/13644
ISSN: 0163-5581
EISSN: 1532-7914
DOI: 10.1080/01635581.2011.596646
Appears in Collections:Journal/Magazine Article

Access
View full-text via PolyU eLinks SFX Query
Show full item record

SCOPUSTM   
Citations

9
Last Week
1
Last month
0
Citations as of Sep 19, 2017

WEB OF SCIENCETM
Citations

7
Last Week
0
Last month
0
Citations as of Sep 21, 2017

Page view(s)

44
Last Week
1
Last month
Checked on Sep 17, 2017

Google ScholarTM

Check

Altmetric



Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.