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Title: Isolation of carbapenem-resistant Pseudomonas spp. from food
Authors: Wong, MHY
Chan, EWC
Chen, S 
Keywords: Carbapenem
Pseudomonas aeruginosa
Pseudomonas otitidis
Pseudomonas putida
Issue Date: 2015
Publisher: Elsevier Ltd
Source: Journal of global antimicrobial resistance, 2015 How to cite?
Journal: Journal of Global Antimicrobial Resistance 
Abstract: Pseudomonas spp. are ubiquitous in nature. Carbapenem resistance in environmental isolates of members of this genus is thought to be rare but the exact resistance rate is unknown. In this study, carbapenem-resistant Pseudomonas spp. were isolated from chicken and pork samples and the mechanisms underlying the carbapenem resistance in these strains were investigated. A total of 16 carbapenem-resistant Pseudomonas aeruginosa, Pseudomonas putida and Pseudomonas otitidis isolates were recovered from eight samples of chicken and pork. The isolates exhibited meropenem minimum inhibitory concentrations (MICs) of 8 to ?32mg/L and imipenem MICs of <0.5-16mg/L yet did not harbour any acquired carbapenemase genes. Meropenem resistance in various strains was found to be mediated by efflux systems only, whereas overexpression of MexAB-OprM efflux pump and lack of OprD porin were responsible for carbapenem resistance in P. aeruginosa. The intrinsic metallo-£]-lactamase gene bla POM in P. otitidis and overexpression of the TtgABC efflux system in P. putida were also responsible for carbapenem resistance in these organisms. In conclusion, thi
ISSN: 2213-7165
DOI: 10.1016/j.jgar.2015.03.006
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