Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/13479
DC FieldValueLanguage
dc.contributorDepartment of Applied Biology and Chemical Technology-
dc.creatorHong, L-
dc.creatorSun, W-
dc.creatorLiu, C-
dc.creatorWang, L-
dc.creatorWong, K-
dc.creatorWang, R-
dc.date.accessioned2014-12-19T07:02:30Z-
dc.date.available2014-12-19T07:02:30Z-
dc.identifier.issn0947-6539-
dc.identifier.urihttp://hdl.handle.net/10397/13479-
dc.language.isoenen_US
dc.publisherWiley-VCHen_US
dc.subjectConjugate additionen_US
dc.subjectEnantioselectivityen_US
dc.subjectEnonesen_US
dc.subjectFriedel-crafts reactionen_US
dc.subjectOrganocatalysisen_US
dc.titleEnantioselective Friedel-Crafts alkylation of 4, 7-dihydroindoles with enones catalyzed by primary-secondary diaminesen_US
dc.typeJournal/Magazine Articleen_US
dc.identifier.spage11105-
dc.identifier.epage11108-
dc.identifier.volume15-
dc.identifier.issue42-
dc.identifier.doi10.1002/chem.200901635-
dcterms.abstractA study was conducted to demonstrate the development of a new chiral primary-secondary diamine catalyst derived from amino acid and its application in the asymmetric Friedel-Crafts alkylation of 4,7-dihydroindoles with ╬▒-╬▓unsaturated enones. A array of primary amines derived from amino acids were investigated in the asymmetric Friedel-Crafts alkylation of 4,7-dihydroindole with benzylideneacetone in toluene. It was found that the length of the alkyl chain influenced the catalytic activity of the primary amine catalyst and the n-propylated catalyst gave the best result. It was also observed that the acid co-catalyst had a great impact on the reaction. The scope and limitations of the method was examined with regard to the enone and 4,7-dihydroindole substrates after establishing optimal reaction conditions.-
dcterms.bibliographicCitationChemistry - a European journal, 2009, v. 15, no. 42, p. 11105-11108-
dcterms.isPartOfChemistry - a European journal-
dcterms.issued2009-
dc.identifier.isiWOS:000271560000008-
dc.identifier.scopus2-s2.0-70350495377-
dc.identifier.pmid19757430-
dc.identifier.eissn1521-3765-
dc.identifier.rosgroupidr47220-
dc.description.ros2009-2010 > Academic research: refereed > Publication in refereed journal-
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