Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/13452
Title: Tacrine and Bis(7)-tacrine attenuate cycloheximide-induced amnesia in mice, with attention to acute toxicity
Authors: Pan, SY
Zhang, Y
Guo, BF
Han, YF 
Ko, KM
Issue Date: 2011
Publisher: Wiley-Blackwell
Source: Basic and clinical pharmacology and toxicology, 2011, v. 109, no. 4, p. 261-265 How to cite?
Journal: Basic and clinical pharmacology and toxicology 
Abstract: Effects of tacrine and bis(7)-tacrine (0.25-20μmol/kg, s.c.) on cognitive behaviour in cycloheximide (CYH)-treated mice were investigated. Cognitive behaviour was assessed by open-field test and step-through task with a 24-hr retention interval. Drugs or vehicle was given 30min. prior to the first session. Although CYH treatment (110mg/kg, i.p.) alone did not affect the locomotor activity of mice, CYH treatment in combination with tacrine (20μmol/kg) decreased the locomotor activity by 37% in the acquisition session, when compared with mice treated with CYH alone. Bis-(7) tacrine cotreatment did not produce any detectable effect on locomotor activity. During the retention trial, tacrine (5μmol/kg) or bis(7)-tacrine (1μmol/kg) enhanced the retention latency (by 3.8- or 1.4-fold, respectively) in CYH-treated mice. In both training and retention trials, CYH treatment increased the number of footshocks (by 50% and 11.3-fold, respectively). However, during the retention (but not training) trial, tacrine (5μmol/kg) or bis(7)-tacrine (1μmol/kg) decreased the footshocks (by 8.6-fold or 39%, respectively) in CYH-treated mice. Combined treatment with CYH and bis(7)-tacrine (but not tacrine) resulted in an increased mortality rate in mice. The results indicated that tacrine and bis(7)-tacrine improved the amnesia caused by CYH treatment. However, the combined treatment with bis(7)-tacrine and CYH administration caused acute toxicity.
URI: http://hdl.handle.net/10397/13452
ISSN: 1742-7835
EISSN: 1742-7843
DOI: 10.1111/j.1742-7843.2011.00715.x
Appears in Collections:Journal/Magazine Article

Access
View full-text via PolyU eLinks SFX Query
Show full item record

SCOPUSTM   
Citations

3
Last Week
0
Last month
0
Citations as of Nov 10, 2017

WEB OF SCIENCETM
Citations

2
Last Week
0
Last month
0
Citations as of Nov 15, 2017

Page view(s)

48
Last Week
1
Last month
Checked on Nov 12, 2017

Google ScholarTM

Check

Altmetric



Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.