Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/13388
Title: Preparation of Galipea officinalis Hancock type tetrahydroquinoline alkaloid analogues as anti-tumour agents
Authors: Lam, KH
Lee, KKH
Gambari, R
Wong, RSM
Cheng, GYM
Tong, SW
Chan, KW
Lau, FY
Lai, PBS
Wong, WY
Chan, ASC
Kok, SHL
Tang, JCO 
Chui, CH
Keywords: Cancer cells
Galipea officinalis
Tetrahydroquinoline alkaloid
Xenograft
Issue Date: 2013
Publisher: Elsevier Gmbh, Urban & Fischer Verlag
Source: Phytomedicine, 2013, v. 20, no. 2, p. 166-171 How to cite?
Journal: Phytomedicine 
Abstract: The preparation of chiral tetrahydroquinolines using Ir-catalysed asymmetric hydrogenation and their possible cytotoxic potential anti-cancer activity were reported. Both of the in vitro cytotoxicity assay on a series of human cancer cell lines including A549 small cell lung cancer, MDA-MB-231 breast cancer, SaoS2 sacroma, SKHep-1 hepatoma and Hep3B hepatocellular carcinoma as well as in vivo animal model using Hep3B hepatocellular tumour xenograft on athymic nude mice suggest that 1,2,3,4-tetrahydroquin-8-ol is a potential anti-tumour alkaloid which may be further developed as a novel cancer chemotherapeutic agent.
URI: http://hdl.handle.net/10397/13388
ISSN: 0944-7113
DOI: 10.1016/j.phymed.2012.09.026
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