Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/13311
Title: A convenient method for the synthesis of DNA-recognizing polyamides in solution
Authors: Xiao, J
Yuan, G
Huang, W
Chan, ASC
Lee, KLD
Issue Date: 2000
Publisher: American Chemical Society
Source: Journal of organic chemistry, 2000, v. 65, no. 18, p. 5506-5513 How to cite?
Journal: Journal of organic chemistry 
Abstract: A convenient method for the synthesis of polyamides containing N-methylpyrrole (Py) and N-methylimidazole (Im) in solution has been developed. Most of the building blocks have been prepared by a haloform reaction in a simple way that column chromatography can be avoided. By use of the DCC/HOBT coupling reaction, the building blocks prepared have been effectively connected to construct a variety of subchains and polyamides without employing amino protection and deprotection. By use of the present method, an eight-ring polyamide, PyPyPyPyγPyImImPyβDp (γ is γ-aminobutyric acid, β is β-alanine, Dp is N,N-dimethylpropyldiamine), has been synthesized by the coupling of two four-ring subchains in one step.
URI: http://hdl.handle.net/10397/13311
ISSN: 0022-3263
EISSN: 1520-6904
DOI: 10.1021/jo000135n
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