Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/13291
Title: The chicken genome contains no HMG1 retropseudogenes but a functional HMG1 gene with long introns
Authors: Lum, HK
Lee, KLD
Yu, G
Issue Date: 2000
Source: Biochimica et biophysica acta. Gene structure and expression, 2000, v. 1493, no. 1-2, p. 64-72
Abstract: We have cloned the genomic sequence coding for the high mobility group 1 (HMG1) protein in chickens. Multiple sequence alignment shows that the chicken HMG1 gene is highly homologous to the human and the mouse HMG1 genes. The gene structure of chicken HMG1 is similar to that of the mouse and the human HMG1 genes, with the same exon-intron boundaries. However, in contrast to other avian genes that have shorter introns, the chicken HMG1 gene has introns that are twice as long as their mammalian homologues. In addition to the functional. intron-containing HMG1 gene, all mammalian genomes contain more than 50 copies of HMG1 retropseudogenes each, while in the chicken genome there are no HMG1 retropseudogenes. This finding suggests that the HMG1 retropseudogenes arose in mammals after their divergence away from the birds.
Keywords: High mobility group 1
Chicken
Retropseudogene
High mobility group 2
High mobility group 2a
High mobility group 4
Publisher: Elsevier
Journal: Biochimica et biophysica acta. Gene structure and expression 
ISSN: 0167-4781
DOI: 10.1016/S0167-4781(00)00164-0
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