Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/13135
Title: Gold-doxorubicin nanoconjugates for overcoming multidrug resistance
Authors: Gu, YJ
Cheng, J
Man, CWY
Wong, WT 
Cheng, SH
Keywords: Chemotherapy
Doxorubicin
Gold nanoparticles
Multidrug resistance
Issue Date: 2012
Source: Nanomedicine : nanotechnology, biology, and medicine, 2012, v. 8, no. 2, p. 204-211 How to cite?
Journal: Nanomedicine: Nanotechnology, Biology, and Medicine 
Abstract: Multidrug resistance (MDR) is a major clinical obstacle to the success of cancer chemotherapy. Here we developed a gold-doxorubicin (DOX) nanoconjugates system to overcome MDR. Gold nanoparticles (AuNPs) were first PEGylated as Au-PEG-NH 2, and DOX was then grafted onto AuNPs via a cleavable disulfide linkage (Au-PEG-SS-DOX). Confocal images revealed that the extent of intracellular uptake of Au-PEG-SS-DOX was greater than that of free DOX in the MDR cells, and inductively coupled plasma mass spectroscopy analysis further confirmed that AuNPs significantly increased the level of drug accumulation in MDR cells at a nanoparticles dose greater than 15 μM. The cytotoxicity study demonstrated that the Au-PEG-SS-DOX nanoconjugates system efficiently released the anticancer drug DOX and enhanced its cytotoxicity against MDR cancer cells. This study highlights the potential of using AuNPs for overcoming of MDR in cancer chemotherapy. From the Clinical Editor: This study demonstrates that gold nanoparticles can be successfully applied to overcome MDR in cancer chemotherapy.
URI: http://hdl.handle.net/10397/13135
ISSN: 1549-9634
DOI: 10.1016/j.nano.2011.06.005
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