Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/12961
Title: Does Guasha offer hepatoprotective effect to chronic inactive hepatitis B carriers? A built-in design to control subject expectation
Authors: Chan, ST
Yuen, JWM 
Gohel, MDI
Wong, HC
Chung, CP
Sun, Y
Ng, JN
Lie, R
Kwong, KK
Issue Date: 2013
Publisher: Mary Ann Liebert, Inc
Source: Journal of alternative and complementary medicine, 2013, v. 19, no. 9, p. 772-776 How to cite?
Journal: Journal of Alternative and Complementary Medicine 
Abstract: Background: A previous case study showed that Guasha, an ancient manual therapeutic technique, could exert hepatoprotective effect in a human chronic active hepatitis B carrier (active-CHB) by modulating the liver enzymes, cytokines, and heme oxygenase-1 (HO-1). The present study serves as a control to the aforementioned case report. The controls were chronic inactive carriers (inactive-CHB) and noncarriers of hepatitis B (NCs). Besides showing a difference in biochemical markers between controls and the previously reported active-CHB case, the asymptomatic condition in both inactive- and active-CHB offers an excellent control for the patient's expectation about Guasha's efficacy. The purpose of this case study was to investigate whether hepatoprotective biochemical markers previously measured in active-CHB in response to Guasha were also present in controls. Participants and Methods: Four inactive-CHB and nine NC participants were included. Each participant received a 15-minute Guasha treatment. Blood samples were obtained immediately before Guasha (day 0) and after Guasha (days 2, 5, and 7). Biochemistry values for liver function, HO-1, and T-helper (Th) cytokines were determined from blood tests. Neither the participants nor the investigator who administered Guasha were aware of the blood test results until after all data were collected for all participants. Results: In both inactive-CHB and NC participants, liver function, serum HO-1, and Th1/Th2 cytokines did not significantly differ before and after Guasha. Conclusions: In contrast to results in active-CHB patients, Guasha did not induce any significant modulation of liver enzymes, HO-1, or cytokines in inactive-CHB and NC participants. The current results suggest that a Guasha-induced hepatoprotective effect depends on the inflammatory event or clinical stage of chronic hepatitis B. Because both active and inactive carriers were completely unaware of their liver status at the time of receiving Guasha, the research protocol is effective in discounting the model that attributes the Guasha therapeutic efficacy to a placebo effect due to participants' expectations.
URI: http://hdl.handle.net/10397/12961
ISSN: 1075-5535
DOI: 10.1089/acm.2012.0186
Appears in Collections:Journal/Magazine Article

Access
View full-text via PolyU eLinks SFX Query
Show full item record

SCOPUSTM   
Citations

2
Last Week
0
Last month
0
Citations as of Apr 22, 2017

WEB OF SCIENCETM
Citations

1
Last Week
0
Last month
0
Citations as of Apr 19, 2017

Page view(s)

34
Last Week
0
Last month
Checked on Apr 16, 2017

Google ScholarTM

Check

Altmetric



Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.