Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/12840
Title: Potent antitumor effects of a novel actinomycin D analog Leu5AMD
Authors: Wang, KR
Zhang, BZ
Zhang, W
Yan, JX
Li, X
Wang, R
Keywords: Actinomycin D
Analog
Antitumor
Apoptosis
SGC-7901 cell
Issue Date: 2008
Publisher: Elsevier Ireland Ltd
Source: Cancer letters, 2008, v. 268, no. 1, p. 38-45 How to cite?
Journal: Cancer Letters 
Abstract: Leu5AMD ([D-Val2, L-MeLeu5]2 AMD) is a novel actinomycin D (AMD) analog, in which both N-methylvalines were replaced by N-methylleucines. In the present study, an attempt has been made to investigate the effects of Leu5AMD on the proliferation of human gastric carcinoma cell line SGC-7901. The results showed that Leu5AMD inhibited the proliferation and induces apoptosis in SGC-7901 cells in a dose-dependent manner. Apoptosis induced by Leu5AMD was further confirmed by annexin V-FITC/PI dual staining assay. After treatment with Leu5AMD, the loss of mitochondrial potential and the decrease of bcl-2 gene expression were observed in apoptotic cells, suggesting that Leu5AMD may be involved in mitochondria and bcl-2 related apoptotic pathway. In addition, the in vivo antitumor effects of Leu5AMD on S-180 bearing mice and the acute toxicity on healthy mice were investigated. Treatment with Leu5AMD markedly suppressed the growth of Sarcoma xenograft. These results suggest that Leu5AMD may be used as a promising chemotherapeutical agent for patients affected by gastric carcinoma and other solid cancer.
URI: http://hdl.handle.net/10397/12840
DOI: 10.1016/j.canlet.2008.03.026
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