Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/12633
Title: Organocatalysis in cross-coupling : DMEDA-catalyzed direct C-H arylation of unactivated benzene
Authors: Liu, W
Cao, H
Zhang, H
Zhang, H
Chung, KH
He, C
Wang, H
Kwong, FY 
Lei, A
Issue Date: 2010
Publisher: Amer Chemical Soc
Source: Journal of the American chemical society, 2010, v. 132, no. 47, p. 16737-16740 How to cite?
Journal: Journal of the American Chemical Society 
Abstract: A striking breakthrough to the frame of traditional cross-couplings/C-H functionalizations using an organocatalyst remains unprecedented. We uncovered a conceptually different approach toward the biaryl syntheses by using DMEDA as the catalyst to promote the direct C-H arylation of unactivated benzene in the presence of potassium tert-butoxide. The arylation of unactivated benzene with aryl iodides, or aryl bromides and even chlorides under the assistance of an iodo-group, could simply take place at 80 °C. The new methodology presumably involves an aryl radical anion as an intermediate. This finding offers an option toward establishing a new horizon for direct C-H/cross-coupling reactions.
URI: http://hdl.handle.net/10397/12633
DOI: 10.1021/ja103050x
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