Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/12549
Title: The preparation and in vitro antiproliferative activity of phthalimide based ketones on MDAMB-231 and SKHep-1 human carcinoma cell lines
Authors: Chan, SH
Lam, KH
Chui, CH
Gambari, R
Yuen, CWM
Wong, RSM
Cheng, GYM
Lau, FY
Au, YK
Cheng, CH
Lai, PBS
Kan, CW 
Kok, SHL
Tang, JCO 
Chan, ASC
Keywords: Anti-tumor activity
Breast carcinoma
Hepatoma
Alpha-Phthalimide ketones
Issue Date: 2009
Publisher: Elsevier Masson
Source: European journal of medicinal chemistry, 2009, v. 44, no. 6, p. 2736-2740 How to cite?
Journal: European journal of medicinal chemistry 
Abstract: The 'one pot' condensation reaction for the synthesis and potent anti proliferative inhibition of alpha-phthalimide based ketones is reported here. 2-Phthalimide-1-(4-fluoro-phenyl)ethanone (5) showed the best growth inhibition on human MDAMB-231 breast carcinoma and SKHep-1 hepatoma cell lines. Preliminary studies showed that the reported bioactivity may be due to the presence of strong electronegative fluorine group at the para-position of the aryl ring.
URI: http://hdl.handle.net/10397/12549
ISSN: 0223-5234
EISSN: 1768-3254
DOI: 10.1016/j.ejmech.2008.10.024
Appears in Collections:Journal/Magazine Article

Access
View full-text via PolyU eLinks SFX Query
Show full item record

SCOPUSTM   
Citations

18
Citations as of Sep 15, 2017

WEB OF SCIENCETM
Citations

18
Last Week
0
Last month
0
Citations as of Sep 5, 2017

Page view(s)

43
Last Week
3
Last month
Checked on Sep 24, 2017

Google ScholarTM

Check

Altmetric



Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.