Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/12492
Title: The preparation of bi-functional organophosphine oxides as potential antitumor agents
Authors: Lam, KH
Chui, CH
Gambari, R
Wong, RSM
Cheng, GYM
Lau, FY
Lai, PBS
Tong, SW
Chan, KW
Wong, WY
Chan, ASC
Tang, JCO
Keywords: Antitumor activity
Bi-functional organophosphine oxides
Hepatocellular carcinoma
Issue Date: 2010
Publisher: Elsevier France-Editions Scientifiques Medicales Elsevier
Source: European journal of medicinal chemistry, 2010, v. 45, no. 11, p. 5527-5530 How to cite?
Journal: European Journal of Medicinal Chemistry 
Abstract: Following our previously reported pyridinyl phosphine oxides as antitumor agents, we targeted the commercially available C2-axial chiral organophosphine ligand catalysts, such as 2,2′-bis(diphenylphosphino)-1, 1′-binaphthyl (BINAP) 1 and 2,2′,6,6′-tetramethoxy-4,4′- bis(diphenylphosphino)-3,3′-bipyridine (P-Phos) 2 as a convenient source for producing organophosphine oxides as antitumor leads. Their corresponding chiral and racemic bi-phosphine oxides 3 and 4 can be obtained easily through a simple oxidation step with hydrogen peroxide, and their antitumor activities towards human hepatocellular carcinoma Hep3B cell line were reported. We found out that compound 3 shows stronger antitumor activity than that of 4, where axial chirality cannot improve their activity. Further athymic nude mice Hep3B xenograft model demonstrates the attractive in vivo antitumor potential of 3.
URI: http://hdl.handle.net/10397/12492
DOI: 10.1016/j.ejmech.2010.08.038
Appears in Collections:Journal/Magazine Article

Access
View full-text via PolyU eLinks SFX Query
Show full item record

SCOPUSTM   
Citations

5
Last Week
1
Last month
0
Citations as of Feb 23, 2017

WEB OF SCIENCETM
Citations

4
Last Week
0
Last month
0
Citations as of Feb 22, 2017

Page view(s)

19
Last Week
1
Last month
Checked on Feb 19, 2017

Google ScholarTM

Check

Altmetric



Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.