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http://hdl.handle.net/10397/12488
Title: | Concise synthesis of two natural steroidal glycosides isolated from Allium schoenoprasum | Authors: | Liu, Q Guo, T Li, D Li, W |
Keywords: | Cytotoxic activity Glycosyl donors Glycosylation Steroidal glycosides |
Issue Date: | 2015 | Publisher: | Kluwer Academic Publishers | Source: | Research on chemical intermediates, 2015 How to cite? | Journal: | Research on Chemical Intermediates | Abstract: | Two natural steroidal glycosides, diosgenin 3-O-α-l-rhamnopyranosyl-(1→2)-[β-d-glucopyranosyl-(1→4)]-β-d-glucopyranoside (1) and laxogenin 3-O-α-l-rhamnopyranosyl-(1→2)-[β-d-glucopyranosyl-(1→4)]-β-d-glucopyranoside (2) with important cytotoxic activity against the HCT 116 and HT-29 human colon cancer cell lines have been efficiently synthesized via straightforward sequential glycosylation reaction with the combined use of N-phenyltrifluoroacetimidates and trichloroacetimidates donors at room temperature. All structures of the synthesized new compounds were identified by 1H NMR, 13C NMR and HRMS spectra. | URI: | http://hdl.handle.net/10397/12488 | ISSN: | 0922-6168 | DOI: | 10.1007/s11164-015-2106-2 |
Appears in Collections: | Journal/Magazine Article |
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