Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/12488
Title: Concise synthesis of two natural steroidal glycosides isolated from Allium schoenoprasum
Authors: Liu, Q
Guo, T
Li, D
Li, W
Keywords: Cytotoxic activity
Glycosyl donors
Glycosylation
Steroidal glycosides
Issue Date: 2015
Publisher: Kluwer Academic Publishers
Source: Research on chemical intermediates, 2015 How to cite?
Journal: Research on Chemical Intermediates 
Abstract: Two natural steroidal glycosides, diosgenin 3-O-α-l-rhamnopyranosyl-(1→2)-[β-d-glucopyranosyl-(1→4)]-β-d-glucopyranoside (1) and laxogenin 3-O-α-l-rhamnopyranosyl-(1→2)-[β-d-glucopyranosyl-(1→4)]-β-d-glucopyranoside (2) with important cytotoxic activity against the HCT 116 and HT-29 human colon cancer cell lines have been efficiently synthesized via straightforward sequential glycosylation reaction with the combined use of N-phenyltrifluoroacetimidates and trichloroacetimidates donors at room temperature. All structures of the synthesized new compounds were identified by 1H NMR, 13C NMR and HRMS spectra.
URI: http://hdl.handle.net/10397/12488
ISSN: 0922-6168
DOI: 10.1007/s11164-015-2106-2
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