Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/12479
Title: Extracorporeal shockwave enhanced regeneration of fibrocartilage in a delayed tendon-bone insertion repair model
Authors: Chow, DHK
Suen, PK
Huang, L
Cheung, WH
Leung, KS
Ng, C
Shi, SQ 
Wong, MWN
Qin, L
Keywords: Enthesis
Extracorporeal shockwave
Fibrocartilage
Tendon bone insertion
Vickers hardness
Issue Date: 2014
Publisher: John Wiley & Sons
Source: Journal of orthopaedic research, 2014, v. 32, no. 4, p. 507-514 How to cite?
Journal: Journal of orthopaedic research 
Abstract: Fibrous tissue is often formed in delayed healing of tendon bone insertion (TBI) instead of fibrocartilage. Extracorporeal shockwave (ESW) provides mechanical cues and upregulates expression of fibrocartilage-related makers and cytokines. We hypothesized that ESW would accelerate fibrocartilage regeneration at the healing interface in a delayed TBI healing model. Partial patellectomy with shielding at the TBI interface was performed on 32 female New Zealand White Rabbits for establishing this delayed TBI healing model. The rabbits were separated into the control and ESW group for evaluations at postoperative week 8 and 12. Shielding was removed at week 4 and a single ESW treatment was applied at week 6. Fibrocartilage regeneration was evaluated histomorphologically and immunohistochemically. Vickers hardness of the TBI matrix was measured by micro-indentation. ESW group showed higher fibrocartilage area, thickness, and proteoglycan deposition than the control in week 8 and 12. ESW increased expression of SOX9 and collagen II significantly in week 8 and 12, respectively. ESW group showed a gradual transition of hardness from bone to fibrocartilage to tendon, and had a higher Vickers hardness than the control group at week 12. In conclusion, ESW enhanced fibrocartilage regeneration at the healing interface in a delayed TBI healing model.
URI: http://hdl.handle.net/10397/12479
ISSN: 0736-0266
EISSN: 1554-527X
DOI: 10.1002/jor.22566
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