Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/12324
Title: Bioelectrocatalytic application of titania nanotube array for molecule detection
Authors: Xie, Y
Zhou, L 
Huang, H 
Keywords: Amperometric detection
Bioelectrocatalysis
Biosensor
Titania nanotube array
Issue Date: 2007
Publisher: Elsevier
Source: Biosensors and bioelectronics, 2007, v. 22, no. 12, p. 2812-2818 How to cite?
Journal: Biosensors and bioelectronics 
Abstract: A bioelectrocatalysis system based on titania nanotube electrode has been developed for the quantitative detection application. Highly ordered titania nanotube array with inner diameter of 60 nm and total length of 540 nm was formed by anodizing titanium foils. The functionalization modification was achieved by embedding glucose oxidases inside tubule channels and electropolymerizing pyrrole for interfacial immobilization. Morphology and microstructure characterization, electrochemical properties and bioelectrocatalytic reactivities of this composite were fully investigated. The direct detection of hydrogen peroxide by electrocatalytic reduction reaction was fulfilled on pure titania nanotube array with a detection limit up to 2.0 × 10 -4 mM. A biosensor based on the glucose oxidase-titania/titanium electrode was constructed for amperometric detection and quantitative determination of glucose in a phosphate buffer solution (pH 6.8) under a potentiostatic condition (-0.4 V versus SCE). The resulting glucose biosensor showed an excellent performance with a response time below 5.6 s and a detection limit of 2.0 × 10 -3 mM. The corresponding detection sensitivity was 45.5 μA mM -1 cm -2. A good operational reliability was also achieved with relative standard deviations below 3.0%. This novel biosensor exhibited quite high response sensitivity and low detection limit for potential applications.
URI: http://hdl.handle.net/10397/12324
ISSN: 0956-5663
EISSN: 1873-4235
DOI: 10.1016/j.bios.2006.11.016
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