Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/12213
Title: Brain iron transport and neurodegeneration
Authors: Qian, ZM
Shen, X
Issue Date: 2001
Publisher: Elsevier Sci Ltd
Source: Trends in molecular medicine, 2001, v. 7, no. 3, p. 103-108 How to cite?
Journal: Trends in Molecular Medicine 
Abstract: Despite years of investigation, it is still not known why iron levels are abnormally high in some regions of the brain in neurodegenerative disorders. Also, it is not clear whether iron accumulation in the brain is an initial event that causes neuronal death or is a consequence of the disease process. Here, we propose that iron and iron-induced oxidative stress constitute a common mechanism that is involved in the development of neurodegeneration. Also, we suggest that, at least in some neurodegenerative disorders, brain iron misregulation is an initial cause of neuronal death and that this misregulation might be the result of either genetic or non-genetic factors.
URI: http://hdl.handle.net/10397/12213
ISSN: 1471-4914
DOI: 10.1016/S1471-4914(00)01910-9
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