Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/12101
Title: Effects of single dose and regular intake of green tea (Camellia sinensis) on DNA damage, DNA repair, and heme oxygenase-1 expression in a randomized controlled human supplementation study
Authors: Ho, CK
Choi, SW
Siu, PM 
Benzie, IFF 
Keywords: DNA damage and repair
Green tea
Heme oxygenase-1
HOGG1
Redox tone
Issue Date: 2014
Publisher: Wiley-VCH Verlag
Source: Molecular nutrition and food research, 2014, v. 58, no. 6, p. 1379-1383 How to cite?
Journal: Molecular Nutrition and Food Research 
Abstract: Regular intake of green tea (Camellia sinensis) lowers DNA damage in humans, but molecular mechanisms of genoprotection are not clear. Protection could be via direct antioxidant effects of tea catechins, but, paradoxically, catechins have pro-oxidant activity in vitro, and it is hypothesized that mechanisms relate to redox-sensitive cytoprotective adaptations. We investigated this hypothesis, focusing particularly on effects on the DNA repair enzyme human oxoguanine glycosylase 1 (hOGG1), and heme oxygenase-1, a protein that has antioxidant and anti-inflammatory effects. A randomized, placebo-controlled, human supplementation study of crossover design was performed. Subjects (n = 16) took a single dose (200 mL of 1.5%, w/v) and 7-days of (2 × 200 mL 1%, w/v per day) green tea (with water as control treatment). Lymphocytic DNA damage was ~30% (p < 0.001) lower at 60 and 120 min after the single dose and in fasting samples collected after 7-day tea supplementation. Lymphocytic hOGG1 activity was higher (p < 0.0001) at 60 and 120 min after tea ingestion. Significant increases (p < 0.0005) were seen in hOGG1 activity and heme oxygenase-1 after 7 days. Results indicate that molecular triggering of redox-sensitive cytoprotective adaptations and posttranslational changes affecting hOGG1 occur in vivo in response to both a single dose and regular intake of green tea, and contribute to the observed genoprotective effects of green tea.
URI: http://hdl.handle.net/10397/12101
ISSN: 1613-4125
DOI: 10.1002/mnfr.201300751
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