Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/12023
Title: Enhanced beauvericin production with in situ adsorption in mycelial liquid culture of Fusarium redolens Dzf2
Authors: Xu, LJ
Liu, YS
Zhou, LG
Wu, JY 
Keywords: Beauvericin
Fermentation process
In situ adsorption
Mycelial culture
Polymeric resin
Shake-flask
Issue Date: 2009
Publisher: Elsevier Sci Ltd
Source: Process biochemistry, 2009, v. 44, no. 10, p. 1063-1067 How to cite?
Journal: Process Biochemistry 
Abstract: Fusarium redolens Dzf2, an endophytic fungal species, is a high producer of the antibiotic compound beauvericin (BEA). However, the BEA produced by the F. redolens Dzf2 fungus was retained mainly as an intracellular product. This study was to evaluate an integrated fermentation-in situ product recovery process for enhancement of BEA production in F. redolens Dzf2 myelical culture. A macroporous polystyrene resin (X-5) was selected as the sorbent and added to the mycelial culture flasks (enclosed in a nylon bag). With 2 g resin added to 40 ml medium in each flask in the early stationary growth phase (day 5), the volumetric BEA yield (on day 7) was increased from 194 to 265 mg l -1, with 65% being adsorbed to the resin phase. With resin renewal plus glucose feeding (on day 7), the BEA production was increased even more dramatically to 400 mg l -1 (on day 9), double of the yield in the batch control culture. The results show that in situ adsorption was an effective strategy for enhancing the BEA production and also facilitating its recovery in the mycelial liquid culture.
URI: http://hdl.handle.net/10397/12023
DOI: 10.1016/j.procbio.2009.05.004
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