Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/12013
Title: Endogenous opioid peptides, endomorphin-1 and -2 and deltorphin I, stimulate angiogenesis in the CAM assay
Authors: Dai, X
Cui, SG
Wang, T
Liu, Q
Song, HJ
Wang, R
Keywords: Angiogenesis
CAM
Deltorphin I
Endomorphin-1
Endomorphin-2
Issue Date: 2008
Publisher: Elsevier
Source: European journal of pharmacology, 2008, v. 579, no. 1-3, p. 269-275 How to cite?
Journal: European journal of pharmacology 
Abstract: The opioid peptides modulate extensive bioactivities, including pain, cardiovascular response, development and so on. The effects of endogenous opioid peptides on angiogenesis were evaluated in the chick embryo chorioallantoic membrane (CAM) assay for the first time in the present study. Endomorphin-1, endomorphin-2 and deltorphin I at the dosage of 1, 10, 100 nmol/embryo could stimulate angiogenesis dose-dependently, respectively. Naloxone, the nonselective opioid receptor antagonist, did not influence angiogenesis alone; but it could antagonize the stimulative effects of the opioid peptides on angiogenesis when it was administrated in combination with the opioid peptides. Taken altogether, the results suggested that endogenous opioid peptides (endomorphin-1 and -2 and deltorphin I) stimulated angiogenesis in the CAM assay, and these effects were modulated with the opioid receptors. These data are important for potential future clinical implementation.
URI: http://hdl.handle.net/10397/12013
ISSN: 0014-2999
DOI: 10.1016/j.ejphar.2007.10.015
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