Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/11925
Title: Polyethylene glycol as an environmentally friendly and recyclable reaction medium for enantioselective hydrogenation
Authors: Zhou, HF
Fan, QH
Tang, WJ
Xu, LJ
He, YM
Deng, GJ
Zhao, LW
Gu, LQ
Chan, ASC
Keywords: Asymmetric hydrogenation
Diphosphine ligands
Immobilized catalyst
Polyethylene glycol
Reaction medium
Recycling
Issue Date: 2006
Publisher: Wiley-VCH
Source: Advanced synthesis & catalysis, 2006, v. 348, no. 15, p. 2172-2182 How to cite?
Journal: Advanced synthesis & catalysis 
Abstract: Polyethylene glycol (PEG) was found to be an inexpensive, non-toxic and recyclable reaction medium for ruthenium- and rhodium-catalyzed asymmetric hydrogenation of 2-arylacrylic acids (Ru-catalyzed C=C bond reduction), enamides (Rh-catalyzed C=C bond reduction), β-keto esters and simple aromatic ketones (Ru-catalyzed C=O bond reduction). In all cases, high catalytic activities and enantioselectivities have been achieved, which are comparable to those obtained in conventional organic solvent systems. The Ru and Rh catalysts prepared with commercially available chiral diphosphine ligands could be readily recycled by simple extraction, as in the case of ionic liquids, and reused up to nine times without obvious loss of catalytic activity and enantioselectivity. The reduced products were obtained from the extracts in high isolated yields. These results indicate that PEGs as new reaction media are attractive alternatives to room temperature ionic liquids.
URI: http://hdl.handle.net/10397/11925
ISSN: 1615-4150
EISSN: 1615-4169
DOI: 10.1002/adsc.200606215
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