Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/11833
Title: Bone regeneration strategy inspired by the study of calcification behavior in deer antler
Authors: Shi, H
Yu, T
Li, Z
Lu, W
Zhang, M
Ye, J
Keywords: Antler
Biomineralization
Bone regeneration
calcification
Issue Date: 2015
Publisher: Elsevier
Source: Materials science and engineering. C, materials for biological applications, 2015, v. 57, p. 67-76 How to cite?
Journal: Materials science and engineering. C, materials for biological applications 
Abstract: Bone regeneration has attracted much attention from various researchers and inspired numerous strategies for bone formation. In this study, rapid calcification of deer antlers was studied to unravel bone biology by investigating mineral composition, morphology and microstructure. Calcification model was hypothesized and preliminarily established by in vitro experiments. In our model, mineral deposition and phase conversions in the gel matrix were mimicked. Results revealed that mineral metabolism including deposition and phase conversion plays key roles in calcification in vivo, which inspired the bone regeneration strategy with three main components, i.e. enhanced mineral nucleation, mineral ions sources and crystals habits. Rapid mineral metabolism of implant apatite biomaterials was supposed as the critical aspect of bone regeneration. This study will provide a relatively ideal model for peer bone regeneration studies.
URI: http://hdl.handle.net/10397/11833
ISSN: 0928-4931
DOI: 10.1016/j.msec.2015.07.043
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