Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/11752
Title: Species variation in biology and physiology of the ciliary epithelium : similarities and differences
Authors: Do, CW 
Civan, MM
Keywords: aqueous humor
Cl- secretion
compartmentation of second messengers
HCO3- secretion
intraocular pressure
topography of ciliary epithelium
Issue Date: 2009
Publisher: Academic Press
Source: Experimental eye research, 2009, v. 88, no. 4, p. 631-640 How to cite?
Journal: Experimental eye research 
Abstract: Glaucoma is a leading cause of irreversible blindness worldwide. Lowering intraocular pressure (IOP) is the only strategy documented to delay the appearance and retard the progression of vision loss. One major approach for lowering IOP is to slow the rate of aqueous humor formation by the ciliary epithelium. As discussed in the present review, the transport basis for this secretion is largely understood. However, several substantive issues are yet to be resolved, including the integrated regulation of secretion, the functional topography of the ciliary epithelium, and the degree and significance of species variation in aqueous humor inflow. This review discusses species differences in net secretion, particularly of Cl- and HCO3- secretion. Identifying animal models most accurately mimicking aqueous humor formation in the human will facilitate development of future novel initiatives to lower IOP.
URI: http://hdl.handle.net/10397/11752
ISSN: 0014-4835
DOI: 10.1016/j.exer.2008.11.005
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