Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/11738
Title: Effectiveness of multiple pre-ischemia electro-acupuncture on attenuating lipid peroxidation induced by cerebral ischemia in adult rats
Authors: Siu, FKW
Lo, SCL 
Leung, MCP
Keywords: Cerebral ischemia
Electro-acupuncture
Lipid peroxidation
Issue Date: 2004
Publisher: Pergamon-Elsevier Science Ltd
Source: Life sciences, 2004, v. 75, no. 11, p. 1323-1332 How to cite?
Journal: Life Sciences 
Abstract: Free radicals induced by cerebral ischemia-reperfusion injury can trigger lipid peroxidation, leading to the production of malondialdehyde (MDA) and 4-hydroxy-2(E)-nonenal (4-HNE). Post-ischemia electroacupuncture (EA) therapy was able to reduce extent of lipid peroxidation. However, the effect of pre-ischemic EA therapy has not been reported. In this study, we aim to investigate the effectiveness of pre-ischemic EA therapy on lipid peroxidation in the rat ischemic injury model. Four groups of Sprague-Dawley rats were designed: Placebo group (without EA therapy), NA group (EA therapy on non-acupoint), GB20 group (EA therapy on Fengchi), and ST36 group (EA therapy on Zusanli). Half of each group (n = 6) received 30-minute EA therapy for 3 times and the other half group for 18 times before the occlusion of right middle cerebral artery. Right brains were taken for determination of concentration of MDA and the total of MDA plus 4-HNE. We found that multiple pre-ischemia EA therapy at either GB20 or ST36 can effectively reduce the amount of MDA produced after MCA occlusion. However, this reduction was not observed in the total amount of MDA and 4-HNE. In conclusion, pre-ischemia EA can partly regulate the lipid peroxidation in cerebral ischemia, where both GB20 and ST36 have a similar beneficial effectiveness.
URI: http://hdl.handle.net/10397/11738
ISSN: 0024-3205
DOI: 10.1016/j.lfs.2004.02.025
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