System and product for treating depression and application

Abstract

The invention relates to the technical field of depression treatment, in particular to a system and a product for treating depression and application. The system for treating depression comprises: an expression vector implanting unit, which is used for implanting a vector capable of expressing a large-conductivity mechanical sensitive ion channel MscL-G22S into a subject for expression; and the acoustic genetics regulation unit is used for performing ultrasonic stimulation on a subject implanted with the carrier. According to the application, a mutant of a large-conductivity mechanical sensitive ion channel MscL-G22S is used as an acoustic genetics tool, the reaction of serotonergic neurons to ultrasound can be enhanced by utilizing the expression of the mutant in a subject, and a very good anti-depression effect on the subject is achieved through acoustic genetics regulation, so that the effect of treating depression is achieved. 本申请涉及抑郁症治疗技术领域，尤其涉及一种用于治疗抑郁症的系统和产品、应用。该用于治疗抑郁症的系统包括：表达载体植入单元：用于将能表达大电导机械敏感离子通道MscL‑G22S的载体植入受试者进行表达；声遗传学调节单元：用于对植入有上述载体的受试者进行超声刺激。本申请利用大电导机械敏感离子通道MscL‑G22S的突变体作为声遗传学工具，利用其在受试者中表达，可以增强血清素能神经元对超声的反应，通过声遗传学调节对受试者具有很好的抗抑郁作用，从而实现治疗抑郁症效果。