Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/11705
Title: Synthesis and characterization of some metal complexes of 4,5-diazafluoren-9-one and their biological effects on human carcinoma cells
Authors: Lu, GL
Ho, CL
Wang, Q
Wong, WY
Chui, CH
Wong, RSM
Gambari, R
Lau, FY
Yuen, CWM
Tong, CSW
Chan, AKW
Tang, JCO 
Ho, KP
Cheng, GYM
Issue Date: 2008
Publisher: Csiro Publishing
Source: Australian journal of chemistry, 2008, v. 61, no. 12, p. 975-980 How to cite?
Journal: Australian Journal of Chemistry 
Abstract: Three new transition metal complexes of 4,5-diazafluoren-9-one, [(DAFO)PdCl2], [(DAFO)PtCl2], and [(DAFO)ZnCl 2], were prepared in good yields by the reactions between appropriate metal chloride precursors and 4,5-diazafluoren-9-one under ambient conditions. The structures of these metal complexes were established by spectroscopic (Fourier-transform IR, NMR, and fast-atom bombardment mass spectrometry) techniques. The possible biological activity of these compounds on three human cancer cell lines including Hep3B, MDAMB-231, and SKHep-1 was investigated. The results obtained showed that both zinc- and platinum-containing compounds exhibit a similar growth inhibitory effect on these three cancer cell lines when compared with the prototypical cis-platin. In contrast, the corresponding palladium congener is virtually biologically inactive in these trials.
URI: http://hdl.handle.net/10397/11705
DOI: 10.1071/CH08342
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