Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/11604
Title: Increased nitric oxide is one of the causes of changes of iron metabolism in strenuously exercised rats
Authors: Qian, ZM
Xiao, DS
Ke, Y
Liao, QK
Keywords: Nitrite and nitrate
Nitro-L-arginine methyl ester
Non-heme iron
Issue Date: 2001
Publisher: American Physiological Society
Source: American journal of physiology. Regulatory integrative and comparative physiology, 2001, v. 280, no. 3 49-3, p. r739-r743 How to cite?
Journal: American journal of physiology. Regulatory integrative and comparative physiology 
Abstract: This study was carried out to investigate the possible role of increased nitric oxide (NO) production in the development of the low iron status in strenuously exercised rats. Female Sprague-Dawley rats were randomly assigned to four groups: sedentary (S1), sedentary + nitro-L-arginine methyl ester (L-NAME; S2), exercise (E1), and exercise + L-NAME (E2). Animals in the E1 and E2 groups swam for 2 h/day for 3 mo. L-NAME in the drinking water (1 mg/ml) was administrated to rats in the S2 and E2 groups for the same period. At the end of third month, hematological indexes and nitrite and nitrate (NOx) contents in the plasma and non-heme iron and NOx levels in the liver, spleen, and bone marrow cells were measured. Three months of exercise induced a significant increase in NOx content and a decrease in iron level both in plasma and tissues. Treatment with L-NAME, an inhibitor of NO synthase (NOS), led to a significant decrease in NOx and an increase in iron level both in plasma and tissues in the exercised rats. The E2 group had a significantly lower NOx content as well as a higher iron level both in plasma and tissues than the E1 group. However, the iron contents in the plasma and tissues of the E2 group were still significantly lower than those found in S1. No difference was found in NOx levels between E2 and S1. These findings showed that exercise was associated with elevation in NOx and reduction in iron in plasma and the tissues. Treatment with L-NAME was able to completely inhibit the effect of exercise on NOx as well as partly recover the decreased iron contents in plasma and tissues resulting from exercise. This suggests that the increased production of NO might be one of the causes of the lower iron status in exercised rats.
URI: http://hdl.handle.net/10397/11604
ISSN: 0363-6119
EISSN: 1522-1490
Appears in Collections:Journal/Magazine Article

Access
View full-text via PolyU eLinks SFX Query
Show full item record

SCOPUSTM   
Citations

34
Last Week
0
Last month
0
Citations as of Apr 24, 2018

WEB OF SCIENCETM
Citations

27
Last Week
0
Last month
0
Citations as of Apr 22, 2018

Page view(s)

64
Last Week
0
Last month
Citations as of Apr 22, 2018

Google ScholarTM

Check


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.