Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/11595
Title: Enantioselective addition of diethylzinc to N-diphenylphosphinoylimines employing N,N-dialkyl-1,2-diphenyl-2-aminoethanols as chiral ligands
Authors: Zhang, X
Gong, L
Mi, A
Cui, X
Jiang, Y
Choi, CKM
Chan, SCA
Keywords: Aminoalcohols
Diethylzinc addition
Imines
Suzuki coupling
Issue Date: 2001
Publisher: Pergamon Press
Source: Tetrahedron letters, 2001, v. 42, no. 36, p. 6369-6372 How to cite?
Journal: Tetrahedron letters 
Abstract: By fine-tuning the substituents on the nitrogen of (1S,2R) and (1R,2S)-1,2-diphenyl-2-aminoethanols, a chiral ligand 2b was obtained, which showed excellent enantioselectivity, with up to 94% e.e, for the asymmetric addition of diethylzinc to N-diphenylphosphinoylimines 1. In one example, the optically active amide 3c was converted into a new amine 5 with 98% e.e. by a reaction sequence involving Suzuki coupling and hydrolysis without racemization.
URI: http://hdl.handle.net/10397/11595
ISSN: 0040-4039
EISSN: 1873-3581
DOI: 10.1016/S0040-4039(01)01273-4
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