Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/11373
Title: Ligustilide inhibits spontaneous and agonists- or K+ depolarization-induced contraction of rat uterus
Authors: Du, J
Bai, B
Kuang, X
Yu, Y
Wang, C
Ke, Y
Xu, Y
Tzang, AHC
Qian, ZM
Keywords: Ca2+ channel
Danggui (Angelica sinensis (Oliv.) Diels, root)
Depolarization
Ligustilide (LIG)
Primary dysmenorrhoea
Uterine contraction in vitro
Issue Date: 2006
Publisher: Elsevier
Source: Journal of ethnopharmacology, 2006, v. 108, no. 1, p. 54-58 How to cite?
Journal: Journal of ethnopharmacology 
Abstract: In the present study, the effects of ligustilide (LIG) on uterine contraction in vitro were investigated. In isolated rat uterine, LIG (2-8 μg/ml) inhibited the spontaneous periodic contraction in a concentration-dependent manner (EC50 = 4.4 μg/ml, 95% confidence interval 2.7-6.1 μg/ml), and attenuated prostaglandin F2alpha (PGF2α)- or acetylcholine chloride (Ach)-induced uterine contractions. At 8 μg/ml, LIG nearly completely blocked the PGF2α-induced contractions (95.3%). In the case of Ach-induced contraction, about 73.9% was inhibited by LIG at this dosage. It was also observed that LIG affected significantly oxytocin-induced increase in the contraction of uterine horns that were incubated not only in the Locke solution but also in a Ca2+-free solution. In addition, LIG caused concentration-dependent inhibition of uterine contraction induced by K+ (56.3 Mm) depolarization, reaching the significant level at 2 μg/ml (EC50 = 3.3 μg/ml, 95% confidence interval 2.5-4.1 μg/ml). The findings clearly show that LIG has multiple effects on the uterine smooth muscles, suggesting that LIG possesses a non-specific antispasmodic function. The data also imply strongly that LIG is one of active ingredients of Danggui and has the potential to be developed into an effective drug for the prevention and treatment of primary dysmenorrhoea.
URI: http://hdl.handle.net/10397/11373
ISSN: 0378-8741
EISSN: 1872-7573
DOI: 10.1016/j.jep.2006.04.011
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