Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/11161
Title: Involvement of nucleophosmin/B23 in the cellular response to curcumin
Authors: Weng, CH
Yung, BYM 
Weng, JJ
Wu, MH
Keywords: Activator protein-1
C-Fos
C-Jun
Curcumin
Nucleophosmin/B23
Issue Date: 2011
Source: Journal of nutritional biochemistry, 2011, v. 22, no. 1, p. 46-52 How to cite?
Journal: Journal of Nutritional Biochemistry 
Abstract: Nucleophosmin (NPM/B23) is a nucleolar phosphoprotein involved in cellular response to many different stimuli. Herein, we studied the molecular mechanism of NPM/B23 induction by curcumin, a natural AP-1 inhibitor with antitumor properties. Exposure to 5-30 μM curcumin significantly and dose-dependently increased the level of NPM/B23 in non-transformed NIH 3T3 cells but not HeLa cells and F9 cells. Besides, the transformed F9 and HeLa cells are more sensitive to curcumin-induced cell death and growth inhibition than NIH 3T3 cells. Overexpression of c-Jun, but not c-Fos, decreased ~40% of NPM/B23 and enhanced the sensitivity of NIH 3T3 cells to 30 μM curcumin. Furthermore, down-regulation of NPM/B23 by transfection with NPM/B23 antisense plasmid enhanced the sensitivity to curcumin-induced cell death and growth inhibition. These results indicated that NPM/B23 expression regulates cellular sensitivity to curcumin. Besides, NPM/B23 knockdown may facilitate as a novel strategy to promote the sensitivity of cancer cells to curcumin.
URI: http://hdl.handle.net/10397/11161
ISSN: 0955-2863
DOI: 10.1016/j.jnutbio.2009.11.010
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