Dual-gate organic electrochemical transistors

Abstract

The invention provides a transistor and a method for detecting and/or determining the concentration of an analyte in a sample by using the transistor. The transistor comprises: a source electrode; a drain electrode; a channel comprising an organic semiconductor between the source electrode and the drain electrode; a plurality of gate electrodes; and an electrolyte, wherein the electrolyte contacts the gate electrodes and the channel, and wherein at least one gate electrode comprises an oxidoreductase and at least one gate electrode does not comprise an oxidoreductase, and methods for detecting and/or determining the concentration of an analyte in a sample using the transistor comprising: (i) applying a voltage to the at least one gate electrode which does not comprise an oxidoreductase; (ii) contacting the test sample in the transistor; (iii) applying the voltage used in (i) to the at least one gate electrode which comprises an oxidoreductase, (iv) removing the voltage from the at least one gate electrode which does not comprise an oxidoreductase; wherein (iii) and (iv) occur simultaneously. 本发明提供了一种晶体管以及使用晶体管检测和/或确定样本中的分析物浓度的方法，该晶体管包括：源极电极；漏极电极；沟道，其包括在源极电极和漏极电极之间的有机半导体；多个栅极电极；以及电解质，其中电解质接触栅极电极和沟道，并且其中至少一个栅极电极包括氧化还原酶，且至少一个栅极电极不包括氧化还原酶，并且所述方法包括：(i)将电压施加到不包括氧化还原酶的至少一个栅极电极；(ii)接触晶体管中的测试样本；(iii)将在(i)中使用的电压施加到包括氧化还原酶的至少一个栅极电极；(iv)将电压从不包括氧化还原酶的至少一个栅极电极去除；其中(iii)和(iv)同时发生。