Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/11058
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dc.contributorSchool of Optometry-
dc.creatorHo, WC-
dc.creatorNg, YF-
dc.creatorChu, PHW-
dc.creatorFong, YY-
dc.creatorYip, KS-
dc.creatorKee, CS-
dc.creatorChan, HHL-
dc.date.accessioned2015-07-14T01:27:44Z-
dc.date.available2015-07-14T01:27:44Z-
dc.identifier.issn0042-6989-
dc.identifier.urihttp://hdl.handle.net/10397/11058-
dc.language.isoenen_US
dc.publisherPergamon Pressen_US
dc.rights© 2010 Elsevier Ltd. All rights reserved.en_US
dc.rights© 2010. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/.en_US
dc.subjectAdaptationen_US
dc.subjectContrasten_US
dc.subjectInner retinaen_US
dc.subjectMultifocal electroretinogram (mfERG)en_US
dc.subjectMyopiaen_US
dc.titleImpairment of retinal adaptive circuitry in the myopic eyeen_US
dc.typeJournal/Magazine Articleen_US
dc.identifier.spage367-
dc.identifier.epage375-
dc.identifier.volume51-
dc.identifier.issue3-
dc.identifier.doi10.1016/j.visres.2010.12.001-
dcterms.abstractPrevious studies have proposed that the inner retina is affected in myopes. This study aimed to investigate the changes in adaptive circuitry of the inner retina in myopia, using the global flash multifocal electroretinogram (global flash mfERG) with different levels of contrast (luminance modulation). Fifty-four myopes had global flash mfERG recorded with different contrasts. The direct component (DC) and the induced component (IC) of the mfERG response were pooled into six regions for analysis. The response amplitudes and implicit times at different contrasts were also analysed. Results showed that myopes had significant reduction in the paracentral DC amplitude for the 29% and 49% contrasts and in the paracentral IC amplitude at all contrasts measured. The peripheral IC amplitude for the 49% contrast was also reduced. No significant change was found in implicit time for either DC or IC response. Refractive error explained about 14% of the variance in DC and 16% of the variance in IC amplitude respectively; axial length could not account for additional variance in either paracentral DC or IC amplitudes in the hierarchical regression models used. We concluded that the paracentral retinal region in myopes showed signs of impaired retinal adaptation, suggesting a functional loss at the inner retinal layer. In addition, functions attributed to the outer retinal layer showed only small changes due to myopia.-
dcterms.accessRightsopen access-
dcterms.bibliographicCitationVision research, 9 Feb. 2011, v. 51, no. 3, p. 367-375-
dcterms.isPartOfVision research-
dcterms.issued2011-02-09-
dc.identifier.isiWOS:000286716300007-
dc.identifier.scopus2-s2.0-78651493108-
dc.identifier.pmid21146555-
dc.identifier.rosgroupidr51830-
dc.description.ros2010-2011 > Academic research: refereed > Publication in refereed journal-
dc.description.oaAccepted Manuscript-
dc.identifier.FolderNumbera0764-n13-
dc.identifier.SubFormID1617-
dc.description.fundingSourceRGC-
dc.description.fundingSourceOthers-
dc.description.fundingTextRGC: PolyU 5415/06M-
dc.description.fundingTextOthers: J-BB7P, J-BB76-
dc.description.pubStatusPublished-
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