Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/10941
Title: A histological study on the effect of pressure therapy on the activities of myofibroblasts and keratinocytes in hypertrophic scar tissues after burn
Authors: Li-Tsang, CWP 
Feng, B
Huang, L
Liu, X
Shu, B
Chan, YTY
Cheung, KK
Keywords: Apoptosis
Hypertrophic scar
Keratinocytes
Myofibroblasts
Pressure intervention
Issue Date: 2015
Publisher: Elsevier
Source: Burns, 2015, v. 41, no. 5, p. 1008-1016 How to cite?
Journal: Burns 
Abstract: Although pressure therapy (PT) has been widely used as the first-line treatment for hypertrophic scars (HS), the histopathological changes involved have seldom been studied. This study aimed to examine the longitudinal effect of PT on the histopathological changes in HS. Ten scar samples were selected from six patients with HS after burn and they were given a standardized PT intervention for 3 months while 16 scar samples were obtained on those without PT. The scar biopsies were collected pre-treatment, 1 and 3 months post-intervention for both clinical and histopathological examinations. Clinical assessments demonstrated significant improvement in the thickness and redness of the scars after PT. Histological examination revealed that cell density in the dermal layer was markedly reduced in the 3-months post-pressurized scar tissues, while the arrangement of the collagen fiber was changed from nodular to wave-like pattern. The α-smooth muscle actin immunoreactivity was significantly decreased after 1-month pressure treatment. There was a significant reduction of myofibroblasts population and a concomitant increase in the apoptotic index in the dermal layer in the 3-months' post-pressurized scars. A significant negative correlation was found between the myofibroblasts population and the apoptotic index. The keratinocyte proliferation was found inhibited after PT. Results demonstrated that PT appeared to promote HS maturation by inhibiting the keratinocyte proliferation and suppressing myofibroblasts population, the latter possibly via apoptosis.
URI: http://hdl.handle.net/10397/10941
ISSN: 0305-4179
DOI: 10.1016/j.burns.2014.11.017
Appears in Collections:Journal/Magazine Article

Access
View full-text via PolyU eLinks SFX Query
Show full item record

SCOPUSTM   
Citations

9
Last Week
0
Last month
0
Citations as of Nov 8, 2017

WEB OF SCIENCETM
Citations

10
Last Week
0
Last month
0
Citations as of Nov 17, 2017

Page view(s)

41
Last Week
1
Last month
Checked on Nov 12, 2017

Google ScholarTM

Check

Altmetric



Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.