Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/10881
Title: Rhodium(iii)-catalyzed formal oxidative [4 + 1] cycloaddition of benzohydroxamic acids and α-diazoesters. A facile synthesis of functionalized benzolactams
Authors: Lam, HW
Man, KY
Chan, WW
Zhou, Z
Yu, WY 
Issue Date: 2014
Source: Organic & biomolecular chemistry, 2014, v. 12, no. 24, p. 4112-4116
Abstract: A Rh(iii)-catalyzed oxidative [4 + 1] cycloaddition of benzohydroxamic acids and α-diazoesters is achieved to afford benzolactams in up to 93% yields. With the N-OAc amido moiety as a directing group, the ortho-C-H is selectively functionalized and the catalytic reaction exhibits excellent tolerance to different functional substituents. A notable rhodacyclic complex is isolated and structurally characterized, suggesting that C-H/N-H cyclometallation is a key step in the catalytic cycle.
Publisher: Royal Society of Chemistry
Journal: Organic & biomolecular chemistry 
ISSN: 1477-0520
EISSN: 1477-0539
DOI: 10.1039/c4ob00512k
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