Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/10857
Title: Effects of chronic ketamine use on frontal and medial temporal cognition
Authors: Chan, KWS
Lee, TMC
Siu, AMH 
Wong, DPL
Kam, CM
Tsang, SKM
Chan, CCH 
Keywords: Addiction
Cognition
Drug
Ketamine
Substance abuse
Issue Date: 2013
Source: Addictive behaviors, 2013, v. 38, no. 5, p. 2128-2132 How to cite?
Journal: Addictive Behaviors 
Abstract: Background: Recreational ketamine use has been on the rise worldwide. Previous studies have demonstrated that it disrupts various memory systems, but few studies have examined how it affects learning and frontal functioning. The present study investigates the effects of repeated ketamine self-administration on frontal fluency, attention, learning, and memory along the verbal/nonverbal axis. Methods: Twenty-five ketamine users and 30 healthy controls took a battery of neuropsychological tests. Frontal fluency was measured by the Verbal Fluency Test for semantic organization ability and the Figural Fluency Test for nonverbal executive functioning. Learning and memory were measured with the Chinese Auditory-Verbal Learning Test for acquisition and retention abilities of verbal information, as well as with the Continuous Visual Memory Test for nonverbal information. Participants also took several tests tapping subdomains of attention. To test for the potential effects of other drug use, 10 polydrug controls were included for comparison with the ketamine users and healthy controls. Results: Ketamine users had impaired verbal fluency, cognitive processing speed, and verbal learning. Verbal learning impairment was strongly correlated with estimated lifetime ketamine use. Ketamine users showed no impairments in figural fluency, sustained attention, selective attention, visual learning, or verbal/nonverbal memory. However, heavier lifetime ketamine use was significantly correlated with deficits in verbal memory (both immediate recall and delayed recall) and visual recognition memory. Deficits in cognitive processing speed and verbal learning persisted even after polydrug controls were included in the control group, but their inclusion did make the impairment in verbal fluency barely reach statistical significance. Conclusions: This study suggests that repeated ketamine use causes differential impairment to multiple domains of frontal and medial temporal functioning, possibly specific to verbal information processing.
URI: http://hdl.handle.net/10397/10857
ISSN: 0306-4603
DOI: 10.1016/j.addbeh.2013.01.014
Appears in Collections:Journal/Magazine Article

Access
View full-text via PolyU eLinks SFX Query
Show full item record

SCOPUSTM   
Citations

13
Last Week
0
Last month
0
Citations as of Jun 24, 2017

WEB OF SCIENCETM
Citations

11
Last Week
0
Last month
1
Citations as of Jun 29, 2017

Page view(s)

34
Last Week
3
Last month
Checked on Jun 25, 2017

Google ScholarTM

Check

Altmetric



Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.