Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/10675
Title: Combining resting-state fMRI and DTI analysis for early-onset schizophrenia
Authors: Ke, M
Shen, H
Fan, J
Huang, X
Zhou, Z
Chen, X
Hu, D
Keywords: Anatomical connectivity
Early-onset schizophrenia
Fractional anisotropy
Functional connectivity
Resting FMRI
Issue Date: 2009
Publisher: Atlantis Press
Source: International journal of computational intelligence systems, 2009, v. 2, no. 4, p. 375-385 How to cite?
Journal: International Journal of Computational Intelligence Systems 
Abstract: We combined measures of resting-state functional magnetic resonance imaging and diffusion tensor imaging (DTI) to investigate alterations of function-structure relationships in patients with early-onset schizophrenia. DTI analysis revealed reduced fractional anisotropy in right frontal white matter. Corresponding gray matter regions showed reduced functional connectivity with other regions in the brain in patients with early-onset schizophrenia, compared with healthy controls. Our results demonstrated abnormal function-structure relationships in early-onset schizophrenia, and supported the view that white matter lesions might disrupt the neural circuits between frontal regions and other brain regions, and affect the functional connectivity in the frontal cortex.
URI: http://hdl.handle.net/10397/10675
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