Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/10447
Title: In vitro anti-cancer property of five synthetic cantharidin analogues : a mini-review
Authors: Kok, SHL
Gambari, R
Chui, CH
Lam, WS
Chen, J
Lau, FY
Wong, RSM
Cheng, GYM
Lai, PBS
Leung, TWT
Chan, ASC
Tang, JCO 
Keywords: Cantharidin
Neoplasms
Structural activity relationship
Issue Date: 2006
Source: Minerva biotecnologica, 2006, v. 18, no. 3, p. 153-157 How to cite?
Journal: Minerva Biotecnologica 
Abstract: Novel drug discovery research for anti-cancer purposes remains urgent and essential, since cancer is still a major fatal cause disease in the 21st century. Cantharidin is a highly toxic compound especially affecting the haematopoietic and renal systems. It can be purified from some naturally occurring insects, including Mylabris species. Here we review our experience in the chemical synthesis and biological screening of five chemically modified cantharidin analogues on a series of human carcinoma cell lines. The pollination between chemical and bio-medical concepts during pharmaceutical design is encouraging in the discovery of novel compounds by maintaining the anti-cancer action, and simultaneously showing the selectivity on non-malignant cells.
URI: http://hdl.handle.net/10397/10447
ISSN: 1120-4826
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