Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/10335
Title: Transmission near-field scanning optical microscopy investigation on cellular uptake behavior of iron oxide nanoparticles
Authors: Zhang, Y
Kyle, JR
Penchev, M
Yazdanpanah, V
Yu, J
Li, Y 
Yang, M
Budak, G
Ozbay, E
Ozkan, M
Ozkan, C
Keywords: AFM
NSOM
Iron oxide
Nanoparticle
Endocytosis
MCF10A
Issue Date: 2012
Source: Bionanoscience, 2012, v. 2, no. 3, p. 135-143 How to cite?
Journal: Bionanoscience 
Abstract: Cellular uptake behavior of iron oxide nanoparticles is investigated using a transmission near-field scanning optical microscopy (NSOM) without the need of fluorescent labeling. By using the transmission NSOM system, we could simultaneously explore the near-field optical analysis of the cell interior and record the topographic information of the cell surface. The cell endocytosis of iron oxide nanoparticles by normal breast MCF10A cells is first studied by this transmission NSOM system, and this dual functional nanoscale-resolution microscopy shows the capability of mapping the spatial localization of nanoparticles in/outside cell surface without the need of fluorescence labeling. Nanoscale optical signature patterns for iron oxide nanoparticle-loaded vesicles inside the cells were observed and analyzed.
URI: http://hdl.handle.net/10397/10335
ISSN: 2191-1630
DOI: 10.1007/s12668-012-0043-8
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