Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/10289
Title: A signal-on fluorescence biosensor for detection of adenosine triphosphate based on click chemistry
Authors: Sun, N
Guo, Q
Shao, J
Qiu, B
Lin, Z
Wong, KY 
Chen, G
Issue Date: 2014
Publisher: Royal Society of Chemistry
Source: Analytical methods, 2014, v. 6, no. 10, p. 3370-3374 How to cite?
Journal: Analytical Methods 
Abstract: A novel signal-on fluorescence biosensor for detection of adenosine triphosphate (ATP) based on the target induced recombination of split aptamer fragments and click chemistry is proposed. The CuS NPs modified on the streptavidin magnesphere paramagnetic particles (PMPs) can be destroyed by acid to form Cu(ii). In the presence of sodium ascorbate, Cu(ii) can be reduced to Cu(i) which in turn catalyzes the reaction between a weak-fluorescent 3-azido-7-hydroxycoumarin and propargyl alcohol to form strongly fluorescent 1,2,3-triazole compounds. The proposed sensor has been applied to the detection of ATP in human serum samples with satisfactory results.
URI: http://hdl.handle.net/10397/10289
ISSN: 1759-9660
DOI: 10.1039/c4ay00220b
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