Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/10245
Title: Modeling of Fusarium redolens Dzf2 mycelial growth kinetics and optimal fed-batch fermentation for beauvericin production
Authors: Xu, LJ
Liu, YS
Zhou, LG
Wu, JY 
Keywords: Beauvericin production
Fed-batch culture
Fusarium fungus
Kinetic model
Mycelial fermentation
Issue Date: 2011
Publisher: Springer
Source: Journal of industrial microbiology & biotechnology, 2011, v. 38, no. 9, p. 1187-1192 How to cite?
Journal: Journal of industrial microbiology & biotechnology 
Abstract: Beauvericin (BEA) is a cyclic hexadepsipeptide mycotoxin with notable phytotoxic and insecticidal activities. Fusarium redolens Dzf2 is a highly BEA-producing fungus isolated from a medicinal plant. The aim of the current study was to develop a simple and valid kinetic model for F. redolens Dzf2 mycelial growth and the optimal fed-batch operation for efficient BEA production. A modified Monod model with substrate (glucose) and product (BEA) inhibition was constructed based on the culture characteristics of F. redolens Dzf2 mycelia in a liquid medium. Model parameters were derived by simulation of the experimental data from batch culture. The model fitted closely with the experimental data over 20-50 g l -1 glucose concentration range in batch fermentation. The kinetic model together with the stoichiometric relationships for biomass, substrate and product was applied to predict the optimal feeding scheme for fed-batch fermentation, leading to 54% higher BEA yield (299 mg l -1) than in the batch culture (194 mg l -1). The modified Monod model incorporating substrate and product inhibition was proven adequate for describing the growth kinetics of F. redolens Dzf2 mycelial culture at suitable but not excessive initial glucose levels in batch and fed-batch cultures.
URI: http://hdl.handle.net/10397/10245
ISSN: 1367-5435
EISSN: 1476-5535
DOI: 10.1007/s10295-010-0895-2
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