Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/10195
Title: Repeated, high-dose dextromethorphan treatment decreases neurogenesis and results in depression-like behavior in rats
Authors: Po, KT
Siu, AMH 
Lau, BWM
Chan, JNM
So, KF
Chan, CCH 
Keywords: Anxiety-like behavior
Depression-like behavior
Dextromethorphan
Drug abuse
Neurogenesis
Issue Date: 2015
Publisher: Springer
Source: Experimental brain research, 2015, v. 233, no. 7, p. 2205-2214 How to cite?
Journal: Experimental brain research 
Abstract: Abuse of cough mixture is increasingly prevalent worldwide. Clinical studies showed that chronic consumption of cough mixture at high dosages may lead to psychiatric symptoms, especially affective disturbances, with the underlying mechanisms remain elusive. The present study aims at exploring the effect of repeated, high-dose dextromethorphan (DXM, a common active component of cough mixture) treatment on adult hippocampal neurogenesis, which is associated with pathophysiology of mood disturbances. After treatment with a high-dose of DXM (40?mg/kg/day) for 2?weeks, Sprague¡VDawley rats showed increased depression-like behavior when compared to the control animals. Neurogenesis in the hippocampus was suppressed by DXM treatment, which was indicated by decreases in number of proliferative cells a
URI: http://hdl.handle.net/10397/10195
ISSN: 0014-4819
EISSN: 1432-1106
DOI: 10.1007/s00221-015-4290-0
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