Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/10061
Title: PET imaging with multimodal upconversion nanoparticles
Authors: Gallo, J
Alam, IS
Jin, J
Gu, YJ
Aboagye, EO
Wong, WT 
Long, NJ
Issue Date: 2014
Publisher: Royal Society of Chemistry
Source: Dalton transactions : an international journal of inorganic chemistry, 2014, v. 43, no. 14, p. 5535-5545 How to cite?
Journal: Dalton transactions : an international journal of inorganic chemistry 
Abstract: A series of new upconversion nanoparticles have been functionalised with tumour-targeting molecules and metal chelates, prepared following standard peptidic and thiol chemistry. The targeting strategy has been delivered via the αvβ3 integrin, which is a heterodimeric cell surface receptor that is up-regulated in a variety of cancers, such as melanoma and breast cancer. The well-known DOTA (1,4,7,10-tetraazacyclododecane-1,4,7,10- tetraacetic acid) motif allows coordination to the radionuclide 68Ga. Radiolabelling experiments were optimised under relatively mild conditions, and are rare amongst nanoparticulate materials. In vivo application of these probes in mouse tumour models revealed their potential as specific cancer contrast agents for PET imaging.
URI: http://hdl.handle.net/10397/10061
ISSN: 1477-9226
EISSN: 1477-9234
DOI: 10.1039/c3dt53095g
Appears in Collections:Journal/Magazine Article

Access
View full-text via PolyU eLinks SFX Query
Show full item record

SCOPUSTM   
Citations

8
Last Week
0
Last month
1
Citations as of Aug 12, 2017

WEB OF SCIENCETM
Citations

7
Last Week
0
Last month
1
Citations as of Jul 28, 2017

Page view(s)

37
Last Week
1
Last month
Checked on Aug 13, 2017

Google ScholarTM

Check

Altmetric



Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.